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KMID : 0388420020120010107
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Konkuk Journal of Medical Sciences
2002 Volume.12 No. 1 p.107 ~ p.113
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Effect of Oral Administration of Dioctahedral Smectite with Phototherapy in the Treatment of Neonatal Hyperbilirubinemia
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Kim Hee-Mo
Jung Young-Chul
Cho Dong-Young
O Myung-Ho
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Abstract
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Background : Dioctahedral smectite is an alumina silicate of phyllitic structure and absorbs bile acid in the intestine, forming a nonabsorbable complex preventing enterohepatic circulation. The purpose of this study is to clarify the value of dioctahedral smectite and the adequate dosage, in combination with phototherapy, as well as to confirm whether it shorten the duration of hospitalization.
Method : Total 45 full-term neonate with a total bilirubin level greater than 12 mg/dl were studied. The neonate were randomly divided into three groups :(1) Only phototherapy group(A)(2) 1.5g/day dioctahedral smectite with phototherapy group(B)(3) 3g/day dioctahedral smectite with phototherapy group(C).
Results : Forty-eight hours and 72 hours after the beginning of the study, the mean bilirubin level among the B, C groups were significantly diminished than that of A group(P<0.05). The duration of phototherapy and hospitalization were significantly diminished in the C group. After phototherapy finished, mean bilirubin level was not significantly diminished.
Conclusion : The data revealed that oral administration of dioctahedral smectitie(especially 3 g/day with phototherapy group : 0 not only increased the efficacy of phototherapy, but also shortened the duration of phototherapy.
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KEYWORD
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Dioctahedral smectite, phototherapy, neonatal jaundice
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